Why is pH so important?

The Importance of pH in PRP Therapy

Physiological pH and Platelet Function:
Normal blood pH is about 7.35. Platelets function best and release growth factors most effectively at or near this physiological pH 5. Acidic environments (pH 6.5–6.8), often resulting from the use of citrate anticoagulants in some PRP kits, significantly reduce platelet aggregation—by more than 50% in some studies 5. This can directly impair the release of key growth factors and diminish the regenerative effect of PRP.
Growth Factor Release:
Acidic PRP not only impairs aggregation but also alters the kinetics and total amount of growth factor release, which is crucial for tissue repair, collagen synthesis, and angiogenesis 1,6. Maintaining a near-physiological pH supports optimal release of PDGF, TGF-β, VEGF, and other healing mediators.
Patient Comfort and Safety:
Acidic PRP can cause more stinging or burning upon injection, leading to increased patient discomfort 7. Maintaining neutral pH improves tolerability, especially in sensitive facial or scalp procedures.

Variables affecting PRP efficacy:
“While normal blood pH is 7.35, some PRP preparation devices use acidic citrate as an anticoagulant to prevent platelet activation, which results in platelet acidification with approximate pH values of 6.5–6.8. Acidification reduces platelet aggregation by >50%.” 5
Patient comfort:
“Patients, however, may experience increased pain because of calcium chloride owing to its low pH of 6.3.” 7
Growth factor release:
“Activation method influences both the physical form and the releasate in terms of GF amount and release kinetic.” 1,6

Recommendations

Juventix and Cellenis are the only major brands consistently delivering PRP at or above physiological pH, supporting optimal platelet function, growth factor release, and patient comfort.

Most competitors (including EmCyte, Harvest, Arthrex, Dr. PRP, RegenLab, Manson, IPPOCARE, Progen, Integrity PRP, Zimmer Biomet) produce PRP that is slightly acidic to neutral (pH 6.8–7.1), which may reduce efficacy and increase injection discomfort.
RegenLab and similar citrate-based systems tend to be more acidic, which can impair platelet aggregation and cause more stinging on injection.

Summary:

pH is a critical, often overlooked factor in PRP therapy, directly influencing platelet function, growth factor release, healing efficacy, and patient comfort.

Juventix stands out by maintaining physiological pH, maximizing platelet recovery, minimizing contamination, and using advanced, chemical-free activation methods—delivering superior and more consistent clinical results compared to most leading PRP systems.

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