What effect do anticoagulants have?
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Role of the anticoagulant in PRP Therapy
In PRP therapy, anticoagulants such as citrate or ACD-A are added to blood samples to prevent clotting during preparation, ensuring that platelets remain viable and functional for growth factor release 1,5,7. By chelating calcium and stabilizing the sample, these agents help maintain platelet integrity and allow for effective separation and concentration of platelets used in regenerative treatments 1,5.
Platelet Yield and Function
ACD-A vs. SC
Growth Factor Release
Inflammatory and Healing Response
Common PRP Systems: Anticoagulant Use and Clinical Implications
(use tablet or computer to see table)
PRP system
Anticoagulant
Juventix
ACD-A
Arthrex Angel
ACD-A
Emcyte
Sodium Citrate
Regen
Sodium Citrate
Cellenis
MNC7
Harvest
ACD-A
Dr. PRP
ACD-A
Integrity
ACD-A
Progen
ACD-A
Apex Xcell
ACD-A
CARE stream
ACD-A
Selphyl
Sodium Citrate
EZ Gel
none
Summary
The type and amount of anticoagulant in a PRP system directly affect platelet yield, growth factor release, and clinical outcomes. Juventix and most leading competitors use ACD-A for optimal efficacy and safety, while systems using ACD may require additional steps to achieve similar results. Avoid EDTA and heparin for regenerative purposes.
Based on the most recent and relevant sources, there is a list of vendors below that offer PRP tubes or systems with EDTA and/or heparin as anticoagulants. It is important to note that while these anticoagulants are available, their use in clinical PRP therapy is generally discouraged due to negative effects on platelet function and regenerative efficacy. Most clinical PRP systems use sodium citrate, ACD-A, or ACD instead. Vendors below may serve research, laboratory, or veterinary markets, and not all are intended for human regenerative medicine.
Vendors—including ZenBio, HBH Medical, Siny Medical, YBO Medical, PRPmed.de, and IPPOCARE—offer PRP tubes with EDTA and/or heparin. DO NOT USE THESE
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