Using PRF (Platelet-Rich Fibrin) filler and PRP (Platelet-Rich Plasma) together in a single treatment is an advanced regenerative strategy that leverages the unique strengths of each to maximize both immediate and long-term skin rejuvenation, healing, and facial volume restoration.

How They Work Together

• PRP is prepared by centrifuging the patient’s blood to concentrate platelets and growth factors in plasma. When injected or applied, PRP delivers a rapid release of growth factors that stimulate collagen synthesis, accelerate healing, improve skin tone and texture, and reduce fine lines and wrinkles 1,5,8.
• PRF is a second-generation platelet therapy made by adding steps to the PRP process, resulting in a fibrin matrix that traps platelets, leukocytes, and stem cells. This matrix acts as a scaffold, enabling a slow, sustained release of growth factors over time, supporting longer-lasting tissue regeneration, improved facial volume, elasticity, and wound healing 2,4,5,6,7.

Why Use PRF Filler and PRP at the Same Time?

Immediate and Long-Term Results

• PRP provides an immediate boost in collagen production and healing due to its quick release of growth factors, making it ideal for rapid skin rejuvenation and post-procedure recovery 5,8.
• PRF delivers a gradual, extended release of regenerative signals, maintaining the healing and volumizing effects for weeks to months after the procedure 2,3,5,7.

Enhanced Volume and Contouring

• PRF filler (sometimes called PRF EZ Gel or PRF bio-filler) acts similarly to a natural dermal filler, restoring facial volume and providing subtle lift, especially in delicate areas like under the eyes and cheeks 4,7.
• PRP can be injected to further stimulate collagen in the same or adjacent areas, enhancing the volumizing and skin-smoothing effects 5,8.

Comprehensive Skin Rejuvenation

• Combining both therapies addresses multiple layers and aspects of aging: PRP targets surface texture, tone, and rapid healing, while PRF supports deeper tissue regeneration, volume, and elasticity 5,6,7.
• This synergy is especially valuable for advanced facial rejuvenation, scar treatment, and difficult-to-treat areas.

Natural and Safe Approach

• Both PRP and PRF are autologous (from your own blood), minimizing risk of allergic reaction or rejection 4,7,8.
• Using both can reduce the need for synthetic fillers or more invasive procedures, offering a holistic, biostimulatory option for patients seeking natural results.

Typical Clinical Scenarios for Combination Use

• Under-Eye Rejuvenation: PRF filler restores lost volume and smooths hollows, while PRP improves skin quality, reduces fine lines, and brightens dark circles 4,7.
• Facial Volume Loss: PRF is injected for volumizing, PRP for overall skin health and collagen boost 5,7.
• Post-Microneedling or Laser: PRP is applied topically for rapid healing, PRF injected for sustained regeneration 1,7.
• Scar and Wrinkle Treatment: PRP accelerates healing and collagen, while PRF provides longer-term remodeling and volume 5,7.

Summary

Using PRF filler and PRP together combines the best qualities of both: PRP’s fast-acting collagen boost and healing with PRF’s slow-release, volumizing, and long-term regenerative effects. This approach is ideal for patients seeking comprehensive, natural facial rejuvenation, especially for under-eye hollows, facial volume loss, and overall skin quality improvement 1,2,4,5,6,7,8.