Mechanism and Rationale

PRF is an autologous, additive-free blood concentrate that, when injected into the skin, acts as a natural dermal filler. Unlike synthetic fillers (such as hyaluronic acid), PRF provides both immediate volumization (from the injected matrix) and long-term tissue regeneration due to its high concentration of platelets, leukocytes, and a fibrin network. This matrix gradually releases growth factors, stimulating collagen synthesis, angiogenesis, and tissue remodeling 1,2,4,7.

Preparation and Injection Protocol

Preparation:

There are several ways to make PRF see the link below to learn about them and their respective advantages or disadvantages.

Injection Technique:

• PRF is injected into the subdermal or deep dermal layers using a fine needle or blunt cannula.
• Common treatment areas include periorbital wrinkles, nasolabial folds, cheeks, lips, and jawline.
• The procedure is typically performed under topical or local anesthesia for comfort.

Clinical Outcomes

• Wrinkle Reduction:
  Studies show significant improvement in both deep and fine wrinkles, especially in the periorbital area, with results visible at 12 weeks and sustained over the long term 1,2,4.
• Skin Quality:
  PRF improves skin texture, elasticity, hydration, and overall radiance. Patients report fresher, firmer, and more youthful skin 1,2,4,7.
• Pigmentation:
  Some studies note improvement in hyperpigmentation due to enhanced collagen content and skin thickness 1.
• Volume Restoration:
  The gelatinous matrix of PRF provides immediate but subtle volume, supporting soft tissue and smoothing contours 1,2.
• Long-Term Regeneration:
  The slow release of growth factors from the fibrin matrix leads to ongoing collagen production and tissue remodeling, with benefits persisting for months 2,4,7.

Comparison to Other Fillers

• PRF vs. PRP:
  PRF offers more sustained results than PRP due to its fibrin matrix, which acts as a reservoir for gradual growth factor release 2.
• PRF vs. Hyaluronic Acid Fillers:
  While HA fillers provide more dramatic and immediate volumization, PRF delivers subtler volume but superior long-term skin quality improvement and regeneration. PRF is also 100% autologous, reducing the risk of allergic reactions 1,2,4,7.

Safety and Side Effects

• Adverse Effects:
  Side effects are typically limited to mild, transient swelling, redness, or bruising at the injection site, resolving within a day or two 1,4,7.
• No Major Complications:
  No significant adverse events or long-term complications have been reported in clinical studies 1,2,4.

Limitations and Considerations

• Subtle Volume:
  PRF is best for subtle, natural-looking enhancement rather than dramatic volumization.
• Technique Sensitivity:
  Proper preparation and timely injection are crucial, as PRF rapidly clots at room temperature.
• Patient Selection:
  Best suited for early to moderate signs of aging, skin quality improvement, and patients seeking natural results.

Summary

PRF is an effective, safe, and natural dermal filler option that offers both immediate and long-term benefits for skin rejuvenation. It excels at improving fine lines, wrinkles, skin texture, and overall skin quality, with minimal side effects and high patient satisfaction. Its regenerative properties make it a valuable tool in advanced aesthetic practice, especially for patients seeking subtle, natural enhancements and long-term tissue health 1,2,4,7.

References:
1 PMC9946120
2 PMC11247247
4 Wiley 2020
7 Byrdie 2025