Deciding when to use PRP (Platelet-Rich Plasma) versus PRF (Platelet-Rich Fibrin) in aesthetics depends on the patient’s goals, the specific skin concerns being addressed, and the desired longevity and depth of results. Here’s a clear guide based on the latest clinical insights (Table at bottom):

PRP

When to Use PRP

• Uneven skin tone
• Hyperpigmentation
• Acne scars
• Fine lines and superficial wrinkles
• Improving skin texture and radiance
• Post-microneedling or laser for faster recovery

Why Choose PRP:

• PRP is rapidly prepared and delivers a quick, concentrated release of growth factors, making it ideal for surface-level rejuvenation and faster visible results.
• It is especially effective for improving skin tone, mild texture issues, and early signs of aging.
• PRP is often used in a series of treatments (typically 3 sessions, spaced 3 months apart) for cumulative improvement1.
• Effects are noticeable within a month but tend to be shorter-lived compared to PRF.

PRF

When to Use PRF

• Best For: Deeper wrinkles and folds
• Facial hollows (under-eye, cheeks, temples)
• Volume loss
• Advanced or long-term skin rejuvenation
• Areas needing sustained collagen stimulation and tissue regeneration
• Surgical recovery and overall facial aesthetics

Why Choose PRF:

• The fibrin scaffold acts as a natural filler, providing volume and structure, making PRF ideal for treating deep wrinkles, hollows, and volume loss.
• Results are longer-lasting and more profound, with ongoing improvement in collagen and tissue quality.
• PRF is preferred for patients seeking natural, gradual, and sustained facial rejuvenation without synthetic fillers.