How do leukocytes (WBC) effect PRP?

Inflammatory Response:
Leukocytes release cytokines and enzymes that can drive inflammation. In some cases (e.g., tendon repair), this can be beneficial, but in others (e.g., intra-articular injections, aesthetics), excess inflammation may cause pain, swelling, and tissue irritation 2,8.
Catabolic Effects:
High WBC concentrations can increase the expression of catabolic (tissue-breaking) factors like interleukin-1 and TNF-alpha, which may contribute to cartilage breakdown and hinder healing in joints 8.
Healing Outcomes:
LP-PRP is often preferred for intra-articular and aesthetic applications due to lower risk of adverse reactions, while LR-PRP may be more effective for chronic tendinopathies and certain soft tissue injuries 1,2.

Recommendations

LP-PRP (like Juventix, Harvest, Selphyl):

Preferred for facial aesthetics, intra-articular, and soft tissue healing where minimizing inflammation is critical

LR-PRP (like Cellenis or other adjustable kits):

May be considered for chronic tendon injuries but carries a higher risk of post-injection pain and inflammation.

Adjustable Systems (EmCyte, Arthrex, Harvest, Dr. PRP, Integrity, Progen, Apex):

Allow clinicians to tailor leukocyte content to the specific clinical scenario.

Summary:

Leukocyte concentration is a major determinant of PRP’s inflammatory potential and clinical suitability. Juventix’s leukocyte-poor approach is supported by evidence for improved comfort and outcomes in aesthetics and joint applications, while some competitors offer customizable or leukocyte-rich options for specific indications. The choice should be matched to the clinical goal and patient needs 1,2,8.

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